Dual Labeling of the CBP/p300 KIX domain for (19)F NMR leads to identification of a new small molecule binding site

Protein-Observed Fluorine NMR Spectroscopy (PrOF NMR) is an emerging technique for screening and characterizing small molecule-protein interactions. The choice of which amino acid to label for PrOF NMR can be critical for analysis. Here we report the first use of a protein containing two different f...

Full description

Saved in:
Bibliographic Details
Published in:Chembiochem
Main Authors: Gee, Clifford T., Arntson, Keith E., Koleski, Edward J., Staebell, Rachel Lynn, Pomerantz, William C.K.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251716/
https://ncbi.nlm.nih.gov/pubmed/29430847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201700686
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items