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Fluorinated Aromatic Amino Acids Are Sensitive (19)F NMR Probes for Bromodomain-Ligand Interactions
[Image: see text] We describe a (19)F NMR method for detecting bromodomain–ligand interactions using fluorine-labeled aromatic amino acids due to the conservation of aromatic residues in the bromodomain binding site. We test the sensitivity, accuracy, and speed of this method with small molecule lig...
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| Publicat a: | ACS Chem Biol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2014
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4273984/ https://ncbi.nlm.nih.gov/pubmed/25290579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5007344 |
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