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Dual screening of BPTF and Brd4 using protein-observed fluorine NMR uncovers new bromodomain probe molecules

Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and inflammation. Selective inhibition of bromodomain function is a newly proposed therapeutic strategy. We describe a (19)F NMR dual screening method for small molecule discovery using fluorinated tryptophan resonances on t...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Urick, Andrew K., Hawk, Laura M. L., Cassel, Melissa K., Mishra, Neeraj K., Liu, Shuai, Adhikari, Neeta, Zhang, Wei, dos Santos, Camila O., Hall, Jennifer L., Pomerantz, William C. K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858447/
https://ncbi.nlm.nih.gov/pubmed/26158404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00483
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