Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor

Bromodomain and PHD finger containing protein transcription factor (BPTF) is an epigenetic protein involved in chromatin remodelling and is a potential anticancer target. The BPTF bromodomain has one reported small molecule inhibitor (AU1, rac-1). Here, advances made on the structure-activity relati...

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Détails bibliographiques
Publié dans:Org Biomol Chem
Auteurs principaux: Kirberger, Steven E., Ycas, Peter D., Johnson, Jorden A., Chen, Chen, Ciccone, Michael, Lu, Rinette Woo Wan, Urick, Andrew K., Zahid, Huda, Shi, Ke, Aihara, Hideki, McAllister, Sean D., Kashani-Sabet, Mohammed, Shi, Junwei, Dickson, Alex, dos Santos, Camila O., Pomerantz, William C.K.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374164/
https://ncbi.nlm.nih.gov/pubmed/30706071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02599a
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