Selective N-terminal BET bromodomain inhibitors by targeting non-conserved residues and structured water displacement

Bromodomain and extra-terminal (BET) family proteins, BRD2-4 and T, are important drug targets; however, the biological functions of each bromodomain remain ill-defined. Chemical probes that selectively inhibit a single BET bromodomain are lacking, although pan inhibitors of the first (D1), and seco...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Angew Chem Int Ed Engl
Egile Nagusiak: Cui, Huarui, Divakaran, Anand, Pandey, Anil K., Johnson, Jorden A., Zahid, Huda, Hoell, Zachariah J., Ellingson, Mikael O., Shi, Ke, Aihara, Hideki, Harki, Daniel A., Pomerantz, William C.K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855888/
https://ncbi.nlm.nih.gov/pubmed/32975004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202008625
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