Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains

[Image: see text] Fragment-based ligand discovery has been successful in targeting diverse proteins. Despite drug-like molecules having more 3D character, traditional fragment libraries are largely composed of flat, aromatic fragments. The use of 3D-enriched fragments for enhancing library diversity...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Johnson, Jorden A., Nicolaou, Christos A., Kirberger, Steven E., Pandey, Anil K., Hu, Haitao, Pomerantz, William C. K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2019
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912871/
https://ncbi.nlm.nih.gov/pubmed/31857841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00414
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