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Dual screening of BPTF and Brd4 using protein-observed fluorine NMR uncovers new bromodomain probe molecules
Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and inflammation. Selective inhibition of bromodomain function is a newly proposed therapeutic strategy. We describe a (19)F NMR dual screening method for small molecule discovery using fluorinated tryptophan resonances on t...
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| Udgivet i: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4858447/ https://ncbi.nlm.nih.gov/pubmed/26158404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00483 |
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