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Protein-observed (19)F-NMR for fragment screening, affinity quantification and druggability assessment
NMR spectroscopy can be used to quantify the binding affinity between proteins and low-complexity molecules, termed ‘fragments’; this versatile screening approach allows researchers to assess the druggability of new protein targets. Protein-observed (19)F-NMR (PrOF NMR) using (19)F-labeled amino aci...
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| Pubblicato in: | Nat Protoc |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8322963/ https://ncbi.nlm.nih.gov/pubmed/27414758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2016.079 |
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