Deficiency for the Cysteine Protease Cathepsin L Impairs Myc-Induced Tumorigenesis in a Mouse Model of Pancreatic Neuroendocrine Cancer

Motivated by the recent implication of cysteine protease cathepsin L as a potential target for anti-cancer drug development, we used a conditional MycER(TAM);Bcl-x(L) model of pancreatic neuroendocrine tumorigenesis (PNET) to assess the role of cathepsin L in Myc-induced tumor progression. By employ...

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Veröffentlicht in:PLoS One
Hauptverfasser: Brindle, Nicola R., Joyce, Johanna A., Rostker, Fanya, Lawlor, Elizabeth R., Swigart-Brown, Lamorna, Evan, Gerard, Hanahan, Douglas, Shchors, Ksenya
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415914/
https://ncbi.nlm.nih.gov/pubmed/25927437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120348
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