Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver

Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we generated mice in which SS is specifically knocked out in the liver (L-SSKO) usi...

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Detaylı Bibliyografya
Yayımlandı:J Lipid Res
Asıl Yazarlar: Nagashima, Shuichi, Yagyu, Hiroaki, Tozawa, Ryuichi, Tazoe, Fumiko, Takahashi, Manabu, Kitamine, Tetsuya, Yamamuro, Daisuke, Sakai, Kent, Sekiya, Motohiro, Okazaki, Hiroaki, Osuga, Jun-ichi, Honda, Akira, Ishibashi, Shun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Biochemistry and Molecular Biology 2015
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409289/
https://ncbi.nlm.nih.gov/pubmed/25755092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M057406
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