Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages

An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing to the development of advanced atherosclerotic lesions. In foam cells, these sterols are stored in esterified forms, which are hydrolyzed by two enzymes: neutral cholesterol ester hydrolase 1 (Nceh1) and hormon...

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Detalhes bibliográficos
Main Authors: Sekiya, Motohiro, Yamamuro, Daisuke, Ohshiro, Taichi, Honda, Akira, Takahashi, Manabu, Kumagai, Masayoshi, Sakai, Kent, Nagashima, Shuichi, Tomoda, Hiroshi, Igarashi, Masaki, Okazaki, Hiroaki, Yagyu, Hiroaki, Osuga, Jun-ichi, Ishibashi, Shun
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174001/
https://ncbi.nlm.nih.gov/pubmed/24891333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M050864
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