Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver

Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we generated mice in which SS is specifically knocked out in the liver (L-SSKO) usi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Nagashima, Shuichi, Yagyu, Hiroaki, Tozawa, Ryuichi, Tazoe, Fumiko, Takahashi, Manabu, Kitamine, Tetsuya, Yamamuro, Daisuke, Sakai, Kent, Sekiya, Motohiro, Okazaki, Hiroaki, Osuga, Jun-ichi, Honda, Akira, Ishibashi, Shun
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409289/
https://ncbi.nlm.nih.gov/pubmed/25755092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M057406
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados