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Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver
Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we generated mice in which SS is specifically knocked out in the liver (L-SSKO) usi...
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| 出版年: | J Lipid Res |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Biochemistry and Molecular Biology
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4409289/ https://ncbi.nlm.nih.gov/pubmed/25755092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M057406 |
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