Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver

Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we generated mice in which SS is specifically knocked out in the liver (L-SSKO) usi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Lipid Res
Egile Nagusiak: Nagashima, Shuichi, Yagyu, Hiroaki, Tozawa, Ryuichi, Tazoe, Fumiko, Takahashi, Manabu, Kitamine, Tetsuya, Yamamuro, Daisuke, Sakai, Kent, Sekiya, Motohiro, Okazaki, Hiroaki, Osuga, Jun-ichi, Honda, Akira, Ishibashi, Shun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Biochemistry and Molecular Biology 2015
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409289/
https://ncbi.nlm.nih.gov/pubmed/25755092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M057406
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