Two disparate ligand binding sites in the human P2Y(1) receptor

In response to adenosine 5′-diphosphate, the P2Y(1) receptor (P2Y(1)R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Here we report the crystal structures of the human P2Y(1)R in complex with a nucleotide antagonist MRS2500 at 2.7Å resolution, and with...

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Pubblicato in:Nature
Autori principali: Zhang, Dandan, Gao, Zhan-Guo, Zhang, Kaihua, Kiselev, Evgeny, Crane, Steven, Wang, Jiang, Paoletta, Silvia, Yi, Cuiying, Ma, Limin, Zhang, Wenru, Han, Gye Won, Liu, Hong, Cherezov, Vadim, Katritch, Vsevolod, Jiang, Hualiang, Stevens, Raymond C., Jacobson, Kenneth A., Zhao, Qiang, Wu, Beili
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408927/
https://ncbi.nlm.nih.gov/pubmed/25822790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14287
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