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Agonist-bound structure of the human P2Y(12) receptor
The P2Y(12) receptor (P2Y(12)R), one of eight members of the P2YR family expressed in humans, has been identified as one of the most prominent clinical drug targets for inhibition of platelet aggregation. Consequently, extensive mutagenesis and modeling studies of the P2Y(12)R have revealed many asp...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128917/ https://ncbi.nlm.nih.gov/pubmed/24784220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13288 |
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