Agonist-bound structure of the human P2Y(12) receptor

The P2Y(12) receptor (P2Y(12)R), one of eight members of the P2YR family expressed in humans, has been identified as one of the most prominent clinical drug targets for inhibition of platelet aggregation. Consequently, extensive mutagenesis and modeling studies of the P2Y(12)R have revealed many asp...

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Autori principali: Zhang, Jin, Zhang, Kaihua, Gao, Zhan-Guo, Paoletta, Silvia, Zhang, Dandan, Han, Gye Won, Li, Tingting, Ma, Limin, Zhang, Wenru, Müller, Christa E., Yang, Huaiyu, Jiang, Hualiang, Cherezov, Vadim, Katritch, Vsevolod, Jacobson, Kenneth A., Stevens, Raymond C., Wu, Beili, Zhao, Qiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128917/
https://ncbi.nlm.nih.gov/pubmed/24784220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13288
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