Structure of the human P2Y(12) receptor in complex with an antithrombotic drug

P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct functional P2YRs expressed in human, which are subdivided into P2Y(1)-like receptors and P2Y(12)-like receptors(1). Their ligands are gen...

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Detalhes bibliográficos
Main Authors: Zhang, Kaihua, Zhang, Jin, Gao, Zhan-Guo, Zhang, Dandan, Zhu, Lan, Han, Gye Won, Moss, Steven M., Paoletta, Silvia, Kiselev, Evgeny, Lu, Weizhen, Fenalti, Gustavo, Zhang, Wenru, Müller, Christa E., Yang, Huaiyu, Jiang, Hualiang, Cherezov, Vadim, Katritch, Vsevolod, Jacobson, Kenneth A., Stevens, Raymond C., Wu, Beili, Zhao, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174307/
https://ncbi.nlm.nih.gov/pubmed/24670650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13083
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