Structure of the human P2Y(12) receptor in complex with an antithrombotic drug

P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors (GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct functional P2YRs expressed in human, which are subdivided into P2Y(1)-like receptors and P2Y(12)-like receptors(1). Their ligands are gen...

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Autori principali: Zhang, Kaihua, Zhang, Jin, Gao, Zhan-Guo, Zhang, Dandan, Zhu, Lan, Han, Gye Won, Moss, Steven M., Paoletta, Silvia, Kiselev, Evgeny, Lu, Weizhen, Fenalti, Gustavo, Zhang, Wenru, Müller, Christa E., Yang, Huaiyu, Jiang, Hualiang, Cherezov, Vadim, Katritch, Vsevolod, Jacobson, Kenneth A., Stevens, Raymond C., Wu, Beili, Zhao, Qiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174307/
https://ncbi.nlm.nih.gov/pubmed/24670650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13083
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