Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia

The prognosis of acute myeloid leukemia (AML) is poor, highlighting the need for novel treatments. Hypomethylating agents, including decitabine are used to treat elderly AML patients with relative success. Targeting nuclear export receptor (exportin 1 [XPO1]) is a novel approach to restore tumor sup...

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Bibliographic Details
Published in:Blood
Main Authors: Ranganathan, Parvathi, Yu, Xueyan, Santhanam, Ramasamy, Hofstetter, Jessica, Walker, Alison, Walsh, Katherine, Bhatnagar, Bhavana, Klisovic, Rebecca, Vasu, Sumithira, Phelps, Mitch A., Devine, Steven, Shacham, Sharon, Kauffman, Michael, Marcucci, Guido, Blum, William, Garzon, Ramiro
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408293/
https://ncbi.nlm.nih.gov/pubmed/25716206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-607648
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