Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia

The prognosis of acute myeloid leukemia (AML) is poor, highlighting the need for novel treatments. Hypomethylating agents, including decitabine are used to treat elderly AML patients with relative success. Targeting nuclear export receptor (exportin 1 [XPO1]) is a novel approach to restore tumor sup...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Ranganathan, Parvathi, Yu, Xueyan, Santhanam, Ramasamy, Hofstetter, Jessica, Walker, Alison, Walsh, Katherine, Bhatnagar, Bhavana, Klisovic, Rebecca, Vasu, Sumithira, Phelps, Mitch A., Devine, Steven, Shacham, Sharon, Kauffman, Michael, Marcucci, Guido, Blum, William, Garzon, Ramiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2015
Ämnen:
Myeloid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408293/
https://ncbi.nlm.nih.gov/pubmed/25716206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-607648
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