Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia

The prognosis of acute myeloid leukemia (AML) is poor, highlighting the need for novel treatments. Hypomethylating agents, including decitabine are used to treat elderly AML patients with relative success. Targeting nuclear export receptor (exportin 1 [XPO1]) is a novel approach to restore tumor sup...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Ranganathan, Parvathi, Yu, Xueyan, Santhanam, Ramasamy, Hofstetter, Jessica, Walker, Alison, Walsh, Katherine, Bhatnagar, Bhavana, Klisovic, Rebecca, Vasu, Sumithira, Phelps, Mitch A., Devine, Steven, Shacham, Sharon, Kauffman, Michael, Marcucci, Guido, Blum, William, Garzon, Ramiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2015
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408293/
https://ncbi.nlm.nih.gov/pubmed/25716206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-607648
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