Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia

The prognosis of acute myeloid leukemia (AML) is poor, highlighting the need for novel treatments. Hypomethylating agents, including decitabine are used to treat elderly AML patients with relative success. Targeting nuclear export receptor (exportin 1 [XPO1]) is a novel approach to restore tumor sup...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Ranganathan, Parvathi, Yu, Xueyan, Santhanam, Ramasamy, Hofstetter, Jessica, Walker, Alison, Walsh, Katherine, Bhatnagar, Bhavana, Klisovic, Rebecca, Vasu, Sumithira, Phelps, Mitch A., Devine, Steven, Shacham, Sharon, Kauffman, Michael, Marcucci, Guido, Blum, William, Garzon, Ramiro
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2015
Teme:
Myeloid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408293/
https://ncbi.nlm.nih.gov/pubmed/25716206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-607648
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