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Species Differences in Hepatobiliary Disposition of Taurocholic Acid in Human and Rat Sandwich-Cultured Hepatocytes: Implications for Drug-Induced Liver Injury

The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the relative contributions of biliary (CL(Bile)) versus basolateral efflux (CL(BL)) clearance to hepatocellular bile aci...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Yang, Kyunghee, Pfeifer, Nathan D., Köck, Kathleen, Brouwer, Kim L. R.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407722/
https://ncbi.nlm.nih.gov/pubmed/25711339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.221564
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