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Species Differences in Hepatobiliary Disposition of Taurocholic Acid in Human and Rat Sandwich-Cultured Hepatocytes: Implications for Drug-Induced Liver Injury
The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the relative contributions of biliary (CL(Bile)) versus basolateral efflux (CL(BL)) clearance to hepatocellular bile aci...
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| Publicado en: | J Pharmacol Exp Ther |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4407722/ https://ncbi.nlm.nih.gov/pubmed/25711339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.221564 |
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