An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR(–) Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown

[Image: see text] Breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 2 (MRP2) are members of the ATP binding cassette (ABC) transporter family located in the canalicular membrane of hepatocytes that mediate biliary excretion of many drugs and endogenous compounds. BC...

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Detalhes bibliográficos
Main Authors: Yang, Kyunghee, Pfeifer, Nathan D., Hardwick, Rhiannon N., Yue, Wei, Stewart, Paul W., Brouwer, Kim L. R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993909/
https://ncbi.nlm.nih.gov/pubmed/24410402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400471e
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