تحميل...

An Experimental Approach To Evaluate the Impact of Impaired Transport Function on Hepatobiliary Drug Disposition Using Mrp2-Deficient TR(–) Rat Sandwich-Cultured Hepatocytes in Combination with Bcrp Knockdown

[Image: see text] Breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 2 (MRP2) are members of the ATP binding cassette (ABC) transporter family located in the canalicular membrane of hepatocytes that mediate biliary excretion of many drugs and endogenous compounds. BC...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Yang, Kyunghee, Pfeifer, Nathan D., Hardwick, Rhiannon N., Yue, Wei, Stewart, Paul W., Brouwer, Kim L. R.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Chemical Society 2014
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993909/
https://ncbi.nlm.nih.gov/pubmed/24410402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400471e
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