Discovery of novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9

Based on a 3D-QSAR pharmacophore derived from a diverse set of known cyclin-dependent kinase 9 (CDK9) inhibitors and a composite pharmacophore extracted from the complex structure of flavopiridol (FVP)-CDK9, thirty novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamine derivatives were designed and...

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Vydáno v:Medchemcomm
Hlavní autoři: Gao, Jiadi, Fang, Cheng, Xiao, Zhiyan, Huang, Li, Chen, Chin-Ho, Wang, Li-Ting, Lee, Kuo-Hsiung
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406325/
https://ncbi.nlm.nih.gov/pubmed/25914804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00412D
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