Loading...
Discovery of novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9
Based on a 3D-QSAR pharmacophore derived from a diverse set of known cyclin-dependent kinase 9 (CDK9) inhibitors and a composite pharmacophore extracted from the complex structure of flavopiridol (FVP)-CDK9, thirty novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamine derivatives were designed and...
Na minha lista:
| Udgivet i: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4406325/ https://ncbi.nlm.nih.gov/pubmed/25914804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00412D |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|