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Discovery of novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9
Based on a 3D-QSAR pharmacophore derived from a diverse set of known cyclin-dependent kinase 9 (CDK9) inhibitors and a composite pharmacophore extracted from the complex structure of flavopiridol (FVP)-CDK9, thirty novel 5-fluoro-N(2),N(4)-diphenylpyrimidine-2,4-diamine derivatives were designed and...
Tallennettuna:
| Julkaisussa: | Medchemcomm |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4406325/ https://ncbi.nlm.nih.gov/pubmed/25914804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00412D |
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