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Interferon-γ Suppresses Intestinal Epithelial Aquaporin-1 Expression via Janus Kinase and STAT3 Activation

Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of the inflammatory cytokine, interferon-γ, which is a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dicay, Michael S., Hirota, Christina L., Ronaghan, Natalie J., Peplowski, Michael A., Zaheer, Raza S., Carati, Colin A., MacNaughton, Wallace K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405000/
https://ncbi.nlm.nih.gov/pubmed/25793528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118713
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