Interferon-γ Suppresses Intestinal Epithelial Aquaporin-1 Expression via Janus Kinase and STAT3 Activation

Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of the inflammatory cytokine, interferon-γ, which is a...

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Publicat a:PLoS One
Autors principals: Dicay, Michael S., Hirota, Christina L., Ronaghan, Natalie J., Peplowski, Michael A., Zaheer, Raza S., Carati, Colin A., MacNaughton, Wallace K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405000/
https://ncbi.nlm.nih.gov/pubmed/25793528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118713
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