Interferon-γ Suppresses Intestinal Epithelial Aquaporin-1 Expression via Janus Kinase and STAT3 Activation

Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of the inflammatory cytokine, interferon-γ, which is a...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Dicay, Michael S., Hirota, Christina L., Ronaghan, Natalie J., Peplowski, Michael A., Zaheer, Raza S., Carati, Colin A., MacNaughton, Wallace K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405000/
https://ncbi.nlm.nih.gov/pubmed/25793528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118713
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