The Pro-Apoptotic BH3-Only Protein Bim Interacts with Components of the Translocase of the Outer Mitochondrial Membrane (TOM)

The pro-apoptotic Bcl-2-family protein Bim belongs to the BH3-only proteins known as initiators of apoptosis. Recent data show that Bim is constitutively inserted in the outer mitochondrial membrane via a C-terminal transmembrane anchor from where it can activate the effector of cytochrome c-release...

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Bibliographic Details
Published in:PLoS One
Main Authors: Frank, Daniel O., Dengjel, Jörn, Wilfling, Florian, Kozjak-Pavlovic, Vera, Häcker, Georg, Weber, Arnim
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398440/
https://ncbi.nlm.nih.gov/pubmed/25875815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123341
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