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Bim(S)-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins
Release of apoptogenic proteins such as cytochrome c from mitochondria is regulated by pro- and anti-apoptotic Bcl-2 family proteins, with pro-apoptotic BH3-only proteins activating Bax and Bak. Current models assume that apoptosis induction occurs via the binding and inactivation of anti-apoptotic...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064208/ https://ncbi.nlm.nih.gov/pubmed/17517961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200610148 |
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