Bim(S)-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins

Release of apoptogenic proteins such as cytochrome c from mitochondria is regulated by pro- and anti-apoptotic Bcl-2 family proteins, with pro-apoptotic BH3-only proteins activating Bax and Bak. Current models assume that apoptosis induction occurs via the binding and inactivation of anti-apoptotic...

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Detalhes bibliográficos
Principais autores: Weber, Arnim, Paschen, Stefan A., Heger, Klaus, Wilfling, Florian, Frankenberg, Tobias, Bauerschmitt, Heike, Seiffert, Barbara M., Kirschnek, Susanne, Wagner, Hermann, Häcker, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064208/
https://ncbi.nlm.nih.gov/pubmed/17517961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200610148
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