BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

During mitochondrial apoptosis, pro-apoptotic BH3-only proteins cause the translocation of cytosolic Bcl-2-associated X protein (Bax) to the outer mitochondrial membrane (OMM) where it is activated to release cytochrome c from the mitochondrial intermembrane space, but the mechanism is under dispute...

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Detalhes bibliográficos
Main Authors: Wilfling, F, Weber, A, Potthoff, S, Vögtle, F-N, Meisinger, C, Paschen, S A, Häcker, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392640/
https://ncbi.nlm.nih.gov/pubmed/22343714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.9
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