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BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax
During mitochondrial apoptosis, pro-apoptotic BH3-only proteins cause the translocation of cytosolic Bcl-2-associated X protein (Bax) to the outer mitochondrial membrane (OMM) where it is activated to release cytochrome c from the mitochondrial intermembrane space, but the mechanism is under dispute...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3392640/ https://ncbi.nlm.nih.gov/pubmed/22343714 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.9 |
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