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TARGETING THE AUTOLYSIS LOOP OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR WITH CONFORMATION-SPECIFIC MONOCLONAL ANTIBODIES

Tight regulation of serine proteases is essential for their physiological functions and unbalanced states of protease activity have been implicated in a variety of human diseases. One key example is the presence of urokinase-type plasminogen activator (uPA) in different human cancer types, with high...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Botkjaer, Kenneth A., Fogh, Sarah, Bekes, Erin C., Chen, Zhuo, Blouse, Grant E., Jensen, Janni M., Mortensen, Kim K., Huang, Mingdong, Deryugina, Elena, Quigley, James P., Declerck, Paul J., Andreasen, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398398/
https://ncbi.nlm.nih.gov/pubmed/21635223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20110129
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