A Novel Mode of Intervention with Serine Protease Activity: TARGETING ZYMOGEN ACTIVATION

Serine proteases are secreted from cells as single-chain zymogens, typically having activities orders of magnitude lower than those of the mature two-chain enzymes. Activation occurs by a conformational change initiated by cleavage of a specific peptide bond. We have derived a monoclonal antibody (m...

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Bibliographic Details
Main Authors: Blouse, Grant E., Bøtkjær, Kenneth A., Deryugina, Elena, Byszuk, Aleksandra A., Jensen, Janni M., Mortensen, Kim K., Quigley, James P., Andreasen, Peter A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640953/
https://ncbi.nlm.nih.gov/pubmed/19047064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804922200
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