A carregar...

A Novel Mode of Intervention with Serine Protease Activity: TARGETING ZYMOGEN ACTIVATION

Serine proteases are secreted from cells as single-chain zymogens, typically having activities orders of magnitude lower than those of the mature two-chain enzymes. Activation occurs by a conformational change initiated by cleavage of a specific peptide bond. We have derived a monoclonal antibody (m...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Blouse, Grant E., Bøtkjær, Kenneth A., Deryugina, Elena, Byszuk, Aleksandra A., Jensen, Janni M., Mortensen, Kim K., Quigley, James P., Andreasen, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640953/
https://ncbi.nlm.nih.gov/pubmed/19047064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804922200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!