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TARGETING TUMOUR CELL INVASION AND DISSEMINATION IN VIVO BY AN APTAMER THAT INHIBITS UROKINASE-TYPE PLASMINOGEN ACTIVATOR THROUGH A NOVEL MULTI-FUNCTIONAL MECHANISM

Data accumulated over the latest two decades have established that the serine protease urokinase-type plasminogen activator (uPA) is a potential therapeutic target in cancer. When designing inhibitors of the proteolytic activity of serine proteases, obtaining sufficient specificity is problematic si...

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Dettagli Bibliografici
Autori principali: Botkjaer, Kenneth A., Deryugina, Elena I., Dupont, Daniel M., Gårdsvoll, Henrik, Bekes, Erin M., Thuesen, Cathrine K., Chen, Zhou, Ploug, Michael, Quigley, James P., Andreasen, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528818/
https://ncbi.nlm.nih.gov/pubmed/23038812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0349
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