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Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase
It has become increasingly clear that protein motions play an essential role in enzyme catalysis. However, how exactly these motions are related to an enzyme’s chemical step is still intensely debated. This chapter examines the possible role of protein motions that display a hierarchy of timescales...
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| 出版年: | Top Curr Chem |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394636/ https://ncbi.nlm.nih.gov/pubmed/23420416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/128_2012_408 |
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