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Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase
It has become increasingly clear that protein motions play an essential role in enzyme catalysis. However, how exactly these motions are related to an enzyme’s chemical step is still intensely debated. This chapter examines the possible role of protein motions that display a hierarchy of timescales...
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| Publicado no: | Top Curr Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394636/ https://ncbi.nlm.nih.gov/pubmed/23420416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/128_2012_408 |
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