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Side-Chain Conformational Heterogeneity of Intermediates in the Escherichia coli Dihydrofolate Reductase Catalytic Cycle

Escherichia coli dihydrofolate reductase (DHFR) provides a paradigm for the integrated study of the role of protein dynamics in enzyme function. Previous studies of backbone and side chain dynamics have yielded unprecedented insights into the mechanism by which DHFR progresses through the structural...

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Autori principali: Tuttle, Lisa M., Dyson, H. Jane, Wright, Peter E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796204/
https://ncbi.nlm.nih.gov/pubmed/23614825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400322e
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