Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung

Epigenetic mechanisms involved in the establishment of lung epithelial cell lineage identities during development are largely unknown. Here, we explored the role of the histone methyltransferase Ezh2 during lung lineage determination. Loss of Ezh2 in the lung epithelium leads to defective lung forma...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Galvis, Laura A., Holik, Aliaksei Z., Short, Kieran M., Pasquet, Julie, Lun, Aaron T. L., Blewitt, Marnie E., Smyth, Ian M., Ritchie, Matthew E., Asselin-Labat, Marie-Liesse
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392602/
https://ncbi.nlm.nih.gov/pubmed/25790853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.122077
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