Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung

Epigenetic mechanisms involved in the establishment of lung epithelial cell lineage identities during development are largely unknown. Here, we explored the role of the histone methyltransferase Ezh2 during lung lineage determination. Loss of Ezh2 in the lung epithelium leads to defective lung forma...

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Bibliographic Details
Published in:Development
Main Authors: Galvis, Laura A., Holik, Aliaksei Z., Short, Kieran M., Pasquet, Julie, Lun, Aaron T. L., Blewitt, Marnie E., Smyth, Ian M., Ritchie, Matthew E., Asselin-Labat, Marie-Liesse
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392602/
https://ncbi.nlm.nih.gov/pubmed/25790853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.122077
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