Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses

Variations in sample quality are frequently encountered in small RNA-sequencing experiments, and pose a major challenge in a differential expression analysis. Removal of high variation samples reduces noise, but at a cost of reducing power, thus limiting our ability to detect biologically meaningful...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Liu, Ruijie, Holik, Aliaksei Z., Su, Shian, Jansz, Natasha, Chen, Kelan, Leong, Huei San, Blewitt, Marnie E., Asselin-Labat, Marie-Liesse, Smyth, Gordon K., Ritchie, Matthew E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Methods Online
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551905/
https://ncbi.nlm.nih.gov/pubmed/25925576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv412
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