Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung

Epigenetic mechanisms involved in the establishment of lung epithelial cell lineage identities during development are largely unknown. Here, we explored the role of the histone methyltransferase Ezh2 during lung lineage determination. Loss of Ezh2 in the lung epithelium leads to defective lung forma...

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Foilsithe in:Development
Main Authors: Galvis, Laura A., Holik, Aliaksei Z., Short, Kieran M., Pasquet, Julie, Lun, Aaron T. L., Blewitt, Marnie E., Smyth, Ian M., Ritchie, Matthew E., Asselin-Labat, Marie-Liesse
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392602/
https://ncbi.nlm.nih.gov/pubmed/25790853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.122077
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