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Design and Mechanism of Tetrahydrothiophene-based GABA Aminotransferase Inactivators

Low levels of γ-aminobutyric acid (GABA), one of two major neurotransmitters that regulate brain neuronal activity, are associated with many neurological disorders, such as epilepsy, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and cocaine addiction. One of the main methods to rai...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Le, Hoang V., Hawker, Dustin D., Wu, Rui, Doud, Emma, Widom, Julia, Sanishvili, Ruslan, Liu, Dali, Kelleher, Neil L., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4390550/
https://ncbi.nlm.nih.gov/pubmed/25781189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b01155
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