Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent GABA Aminotransferase Inactivator for the Treatment of Addiction

γ -Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. Inhibition of GABA aminotransferase (GABA-AT), a pyridoxal 5′-phosphate (PLP)-dependent enzyme that degrades GABA, has been established as a possible strategy for the treatment of substance abuse. The...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Juncosa, Jose I., Takaya, Kenji, Le, Hoang V., Moschitto, Matthew J., Weerawarna, Pathum M., Mascarenhas, Romila, Liu, Dali, Dewey, Stephen L., Silverman, Richard B.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812813/
https://ncbi.nlm.nih.gov/pubmed/29381352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b10965
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