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Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid

The inhibition of ornithine aminotransferase (OAT), a pyridoxal 5′-phosphate-dependent enzyme, has been implicated as a treatment for hepatocellular carcinoma (HCC), the most common form of liver cancer, for which there is no effective treatment. From a previous evaluation of our aminotransferase in...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Moschitto, Matthew J., Doubleday, Peter F., Catlin, Daniel S., Kelleher, Neil L., Liu, Dali, Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754100/
https://ncbi.nlm.nih.gov/pubmed/31251613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b03254
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