Mechanism of Inactivation of γ-Aminobutyric Acid Aminotransferase by (1S,3S)-3-Amino-4-difluoromethylene-1-cyclopentanoic Acid (CPP-115)

[Image: see text] γ-Aminobutyric acid aminotransferase (GABA-AT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that degrades GABA, the principal inhibitory neurotransmitter in mammalian cells. When the concentration of GABA falls below a threshold level, convulsions can occur. Inhibition of GAB...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Lee, Hyunbeom, Doud, Emma H., Wu, Rui, Sanishvili, Ruslan, Juncosa, Jose I., Liu, Dali, Kelleher, Neil L., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353033/
https://ncbi.nlm.nih.gov/pubmed/25616005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja512299n
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