CPP-115, a Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction

Vigabatrin, a GABA aminotransferase (GABA-AT) inactivator, is used to treat infantile spasms and refractory complex partial seizures and is in clinical trials to treat addiction. We evaluated a novel GABA-AT inactivator (CPP-115) and observed that it does not exhibit other GABAergic or off-target ac...

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Hauptverfasser: Pan, Yue, Gerasimov, Madina R., Kvist, Trine, Wellendorph, Petrine, Madsen, Karsten K., Pera, Elena, Lee, Hyunbeom, Schousboe, Arne, Chebib, Mary, Bräuner-Osborne, Hans, Craft, Cheryl M., Brodie, Jonathan D., Schiffer, Wynne K., Dewey, Stephen L., Miller, Steven R., Silverman, Richard B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257419/
https://ncbi.nlm.nih.gov/pubmed/22128851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201231w
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