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Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase

[Image: see text] Aminotransferases are pyridoxal 5′-phosphate-dependent enzymes that catalyze reversible transamination reactions between an amino acid and an α-keto acid, playing a critical role in cellular nitrogen metabolism. It is evident that γ-aminobutyric acid aminotransferase (GABA-AT), whi...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Shen, Sida, Doubleday, Peter F., Weerawarna, Pathum M., Zhu, Wei, Kelleher, Neil L., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549257/
https://ncbi.nlm.nih.gov/pubmed/33062178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00672
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