The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM

Compartmentalized cAMP signaling regulates mitochondrial dynamics, morphology, and oxidative phosphorylation. However, regulators of the mitochondrial cAMP pathway, and its broad impact on organelle function, remain to be explored. Here, we report that Drosophila Prune is a cyclic nucleotide phospho...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Zhang, Fan, Qi, Yun, Zhou, Kiet, Zhang, Guofeng, Linask, Kaari, Xu, Hong
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
Subjects:
Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4388618/
https://ncbi.nlm.nih.gov/pubmed/25648146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201439636
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